Comprehensive coronary plaque assessment in patients with obstructive sleep apnea.

Abstract

Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using coronary artery calcium score (CAC) measurements. However, limited data are available regarding the association of OSA with non-calcified plaque burden. We therefore aimed to assess the relationship between CAD severity as assessed by coronary computed tomography angiography (CTA) and OSA. Forty-one adult subjects (59±9years, 15 men) underwent a 256-slice coronary CTA, which was followed by a diagnostic attended cardiorespiratory polygraphy (n=13) or polysomnography (n=28). Segment involvement score (SIS), segment stenosis score (SSS) and CAC were used to quantify total CAD burden. Correlation analysis was used to assess potential associations between CAD and OSA. Twenty-two patients were diagnosed with OSA. SIS and SSS were elevated in OSA (2.90±2.78 versus 1.79±2.39 and 4.91±5.94 versus 1.79±4.54, OSA versus controls, SIS and SSS respectively, both p<0.01) and correlated with OSA severity as measured by the apnea-hypopnea index (AHI, r=0.41 and 0.43, p<0.01) and oxygen desaturation index (ODI, r=0.45 and 0.46, p<0.01). However, no significant correlation was observed between CAC and OSA. Compared to CAC, SIS and SSS provide additional information on coronary plaque burden in OSA, which shows a significant association with OSA.