Comprehensive Collection of Current Methods for Contractility and Electrophysiology Recordings in Human Cardiac Cells

Abstract

ARTICLES DISCUSSED: Gerges, N. A. et al. Measurement of heart contractility in isolated adult human primary cardiomyocytes. Journal of Visualized Experiments. (186), e64394 (2022). Lickiss, B. et al. Hybrid cell analysis system to assess structural and contractile changes of human iPSC-derived cardiomyocytes for preclinical cardiac risk evaluation. Journal of Visualized Experiments. (188), e64283 (2022). Feaster, T. K., Casciola, M., Narkar, A., Blinova, K. Evaluation of cardiac contractility modulation therapy in 2D human stem cell-derived cardiomyocytes. Journal of Visualized Experiments. (190), e64848 (2022). Schaefer, J., Danker, T., Gebhardt, K., Kraushaar, U. Laser-induced action potential-like measurements of cardiomyocytes on microelectrode arrays for increased predictivity of safety pharmacology. Journal of Visualized Experiments. (187), e64355 (2022). Berry, B. J. et al. Preclinical drug testing in scalable 3D engineered muscle tissues. Journal of Visualized Experiments. e64399 (2022). Zhao, S. R., Mondéjar-Parreño, G., Li, D., Shen, M., Wu, J. C. Technical applications of microelectrode array and patch clamp recordings on human induced pluripotent stem cell-derived cardiomyocytes. Journal of Visualized Experiments. (186), e64265 (2022).