Abstract
This study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients. We evaluated 53 ACS patients between April 2019 and September 2020. LSFG measured the mean blur rate (MBR) and ocular blowout time (BOT) and resistivity index (RI). 110 consequent patients without a history of coronary artery disease who visited ophthalmology as a control group. Significant positive correlations were observed between ocular RI and systemic parameters in ACS patients, including intima-media thickness (r = 0.34, P = 0.015), brachial-ankle pulse-wave velocity (r = 0.41, P = 0.002), cystatin C (r = 0.32, P = 0.020), and E/e’ (r = 0.34, P = 0.013). Ocular RI was significantly higher in the ACS group than in the control group in male in their 40 s (0.37 ± 0.02 vs. 0.29 ± 0.01, P < 0.001) and 50 s (0.36 ± 0.02 vs. 0.30 ± 0.01, P = 0.01). We found that the ocular RI was associated with systemic atherosclerosis, early renal dysfunction, and diastolic cardiac dysfunction in ACS patients, suggesting that it could be a useful non-invasive comprehensive arteriosclerotic marker.
Highlights
This study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients
Abbreviations A Peak mitral A wave velocity acute myocardial infarction (AMI) Acute myocardial infarction ARB Angiotensin receptor blocker baPWV Brachial-ankle pulse-wave velocity blowout time (BOT) Blowout time blood urea nitrogen (BUN) Blood urea nitrogen chronic kidney disease (CKD) Chronic kidney disease E Peak mitral E wave velocity e’ Peak early diastolic myocardial velocity at septal position recorded by tissue Doppler imaging E/e’, ratio Ratio of peak mitral E wave velocity to peak early diastolic myocardial velocity at the septal position by tissue Doppler imaging estimated glomerular filtration rate (eGFR) Estimated glomerular filtration rate HbA1c Hemoglobin A1c HDL-Cho High-density lipoprotein cholesterol heart failure with preserved ejection fraction (HFpEF) Heart failure with preserved ejection fraction IMT Intima-media thickness IOP Intraocular pressure liver-type fatty acid-binding protein (L-FABP) Liver-type fatty acid-binding protein LDL-Cho Low-density lipoprotein cholesterol
This study aimed to investigate the association between systemic atherosclerotic parameters, renal biomarkers, and cardiac function assessed by transthoracic echocardiography, and ocular resistivity index (RI) and BOT evaluated by LSFG in ACS patients
Summary
This study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients. Abbreviations A Peak mitral A wave velocity AMI Acute myocardial infarction ARB Angiotensin receptor blocker baPWV Brachial-ankle pulse-wave velocity BOT Blowout time BUN Blood urea nitrogen CKD Chronic kidney disease E Peak mitral E wave velocity e’ Peak early diastolic myocardial velocity at septal position recorded by tissue Doppler imaging E/e’, ratio Ratio of peak mitral E wave velocity to peak early diastolic myocardial velocity at the septal position by tissue Doppler imaging eGFR Estimated glomerular filtration rate HbA1c Hemoglobin A1c HDL-Cho High-density lipoprotein cholesterol HFpEF Heart failure with preserved ejection fraction IMT Intima-media thickness IOP Intraocular pressure L-FABP Liver-type fatty acid-binding protein LDL-Cho Low-density lipoprotein cholesterol. This study aimed to investigate the association between systemic atherosclerotic parameters (carotid intima-media thickness [IMT] and brachial-ankle pulse-wave velocity [baPWV]), renal biomarkers, and cardiac function assessed by transthoracic echocardiography, and ocular RI and BOT evaluated by LSFG in ACS patients
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