Abstract
In this paper, we applied a method for quantifying several left intraventricular hemodynamic parameters from 4D Flow data and its application in a proof-of-concept study in dilated cardiomyopathy (DCM) patients. In total, 12 healthy volunteers and 13 DCM patients under treatment underwent short-axis cine b-SSFP and 4D Flow MRI. Following 3D segmentation of the left ventricular (LV) cavity and registration of both sequences, several hemodynamic parameters were calculated at peak systole, e-wave, and end-diastole using a finite element approach. Sensitivity, inter- and intra-observer reproducibility of hemodynamic parameters were evaluated by analyzing LV segmentation. A local analysis was performed by dividing the LV cavity into 16 regions. We found significant differences between volunteers and patients in velocity, vorticity, viscous dissipation, energy loss, and kinetic energy at peak systole and e-wave. Furthermore, although five patients showed a recovered ejection fraction after treatment, their hemodynamic parameters remained low. We obtained several hemodynamic parameters with high inter- and intra-observer reproducibility. The sensitivity study revealed that hemodynamic parameters showed a higher accuracy when the segmentation underestimates the LV volumes. Our approach was able to identify abnormal flow patterns in DCM patients compared to volunteers and can be applied to any other cardiovascular diseases.
Highlights
Dilated cardiomyopathy (DCM) is more common than non-ischemic cardiomyopathy and leads to left ventricular dilation and systolic and diastolic dysfunction [1,2]
These changes indicated that the left ventricular (LV) in dilated cardiomyopathy (DCM) patients was enlarged and its cardiac function was reduced, which is consistent with the pathological characteristics of DCM [1,2]
DCM mainly affects the systolic function, we evaluated the hemodynamic parameters at systole and diastole, as several papers have shown that diastolic function is affected by this disease
Summary
Dilated cardiomyopathy (DCM) is more common than non-ischemic cardiomyopathy and leads to left ventricular dilation and systolic and diastolic dysfunction [1,2]. The progression is associated with an incremented risk of heart failure and sudden cardiac death [5]. Poor survival and high mortality rate reveal that effective treatment of DCM-related heart failure remains challenging. Pharmacological and resynchronization therapies have improved DCM treatment by halting disease progression and leading to reverse remodeling [1]. The preferred imaging technique for assessing the heat in DCM patients is cardiovascular magnetic resonance (CMR). CMR allows the acquisition of anatomical, cine, and velocity images, including 4D Flow MR [5,6,7,8]
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