Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis.

Ben-Gang Wang,Qian Xu,Li-Yue Jiang

doi:10.1042/bsr20180712

Ben-Gang Wang, Qian Xu + Show 1 more

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https://doi.org/10.1042/bsr20180712

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Abstract

MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic review with a meta-analysis for the association of miRNA SNPs with HCC risk. Thirty-seven studies were included with a total of 11821 HCC patients and 15359 controls in this meta-analysis. We found hsa-mir-146a rs2910164 was associated with a decreased HCC risk in the recessive model (P=0.017, OR = 0.90, 95% confidence interval (CI) = 0.83–0.98). While hsa-mir-34b/c rs4938723 was related with an increased HCC risk in the co-dominant model (P=0.016, odds ratio (OR) = 1.19, 95%CI = 1.03–1.37). When analyzing the Hepatitis B virus (HBV)-related HCC risk, hsa-mir-196a-2 rs11614913 was associated with a decreased HBV-related HCC risk in the co-dominant and allelic models. And hsa-mir-149 rs2292832 was found to be associated with a decreased HBV-related HCC risk in the dominant and recessive models. In conclusion, hsa-mir-146a rs2910164 and hsa-mir-34b/c rs4938723 could be biomarkers for the HCC risk while hsa-mir-196a-2 rs11614913 and hsa-mir-149 rs2292832 had potential to be biomarkers for HBV-related HCC risk.

Highlights

Received: 08 May 2018Revised: 23 June 2018Accepted: 04 July 2018Accepted Manuscript Online: Version of Record published: MiRNAs are 19–24 nts short nucleotide sequences, which could complementarily combine with multiple target sequences and one miRNA could regulate multiple different target genes [1]
We found hsa-mir-146a rs2910164 was associated with a decreased Hepatocellular cancer (HCC) risk in the recessive model (P=0.017, odds ratios (ORs) = 0.90, 95% confidence interval (CI) = 0.83–0.98)
While hsa-mir-34b/c rs4938723 was related with an increased HCC risk in the co-dominant model (P=0.016, odds ratio (OR) = 1.19, 95%CI = 1.03–1.37)

Summary

Introduction

Received: 08 May 2018Revised: 23 June 2018Accepted: 04 July 2018Accepted Manuscript Online: Version of Record published: MiRNAs are 19–24 nts short nucleotide sequences, which could complementarily combine with multiple target sequences and one miRNA could regulate multiple different target genes [1]. There are two types of miRNA-SNP: pri-miRNA SNPs and pre-miRNA SNPs. pri-miRNA SNPs are located over approximately 500–3000bp of the miRNA gene, while pre-miRNA. The function of miRNA-SNPs depends on its location; pri-miRNA SNPs may have more important roles than pre-miRNA SNPs. Hepatocellular cancer (HCC) is the second leading cause of cancer deaths worldwide [4]. In HCC patients, approximately 50% are related with Hepatitis B virus (HBV) [5,6], and HBV is still the major cause of HCC, especially in Asia-Pacific and Sub-Saharan Africa [7]. The etiology of HBV-related HCC is reported different from that of no chronic HBV infection, which is mainly caused by the HBV, host-related such as SNPs, and the dietary and lifestyle factors [8]. The prediction for the HCC risk, especially the HBV-related HCC risk is essential to prevent the incidence of HCC and increase the early diagnosis of HCC

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