Abstract
The rapid spread of Zika virus (ZIKV) has caused much concern in the global health community, due in part to a link to fetal microcephaly and other neurological illnesses. While an increasing amount of ZIKV genomic sequence data is being generated, an understanding of the virus molecular biology is still greatly lacking. A significant step towards establishing ZIKV proteomics would be the compilation of all proteins produced by the virus, and the resultant virus genotypes. Here we report for the first time such data, using new computational methods for the annotation of mature peptide proteins, genotypes, and recombination events for all ZIKV genomes. The data is made publicly available through the Virus Pathogen Resource at www.viprbrc.org.
Highlights
The recent emergence of Zika virus (ZIKV) poses a global public health threat [1]
Because the cleavage sites were highly conserved and reliable we developed a Perl script to produce the protease cleavage site coordinates and resultant mature peptide sequences for ZIKV polyproteins
ZIKV mature peptides were computed from the parent polyproteins
Summary
The recent emergence of Zika virus (ZIKV) poses a global public health threat [1]. ZIKV is a mosquito-borne arbovirus of the Flaviviridae family, first isolated from a Rhesus macaque monkey in the Zika forest of Uganda in 1947. Until recently ZIKV outbreaks had only been seen in Africa, Asia, and the Pacific Islands [2]. Zika’s epidemiologic range has expanded to Brazil and other South, Central and North American countries. Symptomatic patients experience mild fever, rash, and arthralgia. The virus has evolved, and new and alarming correlations between ZIKV infection and microcephaly and Guillian-Barre syndrome imply a causal relationship between infection and birth defects
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