Abstract
Colorectal cancer (CRC) is one of the most common types of human cancers. However, the mechanisms underlying CRC progression remained elusive. This study identified differently expressed messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs), and small nucleolar RNAs (snoRNAs) between pre-therapeutic biopsies and post-therapeutic resections of locally advanced CRC by analyzing a public dataset, GSE94104. We identified 427 dysregulated mRNAs, 4 dysregulated lncRNAs, and 19 dysregulated snoRNAs between pre- and post-therapeutic locally advanced CRC samples. By constructing a protein–protein interaction network and co-expressing networks, we identified 10 key mRNAs, 4 key lncRNAs, and 7 key snoRNAs. Bioinformatics analysis showed therapy-related mRNAs were associated with nucleosome assembly, chromatin silencing at recombinant DNA, negative regulation of gene expression, and DNA replication. Therapy-related lncRNAs were associated with cell adhesion, extracellular matrix organization, angiogenesis, and sister chromatid cohesion. In addition, therapy-related snoRNAs were associated with DNA replication, nucleosome assembly, and telomere organization. We thought this study provided useful information for identifying novel biomarkers for CRC.
Highlights
Colorectal cancer (CRC) is one of the most common types of human cancers (Ma et al, 2014)
The present study aimed to identify therapy-related messenger RNAs (mRNAs) in advanced CRC using a public dataset, GSE94104
We identified 427 dysregulated mRNAs between pre- and post-therapeutic locally advanced CRC (LACC) samples, including 235 upregulated mRNAs and 192 downregulated mRNAs after therapy in LACC
Summary
Colorectal cancer (CRC) is one of the most common types of human cancers (Ma et al, 2014). The morbidity and mortality of CRC have increased rapidly in recent years (Budai et al, 2004). In 2016, a total of 134,490 new cases of CRC and 49,190 deaths caused by CRC were reported worldwide. The diagnostic technologies and therapeutic strategies of CRC have made significant progress (Ress et al, 2015). The prognosis of CRC remained poor with 5-year survival rates being only 10–15%, and the recurrent disease rates of CRC remained high.
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