Comprehensive Analysis of TGF β &amp; β – Catenin Components in Various Human Cancer Tissues

Jamila Sameer Daraghmeh,Bayan Mustafa Mansour,Asmaa Yousef Kmail,Iqab Ghalib Daraghmeh

doi:10.5296/jab.v9i1.18354

Comprehensive Analysis of TGF β & β – Catenin Components in Various Human Cancer Tissues

Jamila Sameer Daraghmeh, Bayan Mustafa Mansour + Show 2 more

Open Access

https://doi.org/10.5296/jab.v9i1.18354

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Abstract

Studies over the last years revealed significant insights into the β-Catenin & TGF β signal transduction pathways and that such pathways are abnormal activated in abundant cancer types. According to the straight forward effect of these pathways in various tumor types, both pathways are currently considered targets for innovative cancer therapies. This view study emphasizes 13 proteins that are implicated in these two pathways. As there has been widespread research into the proteins that involved in these pathways, we have utilized data existing in the Human Protein Atlas database in this paper to examine the expression of 53 crucial proteins that are recognized to be involved in the activation of these pathways in a distinct group of 45 cancer types. Our findings revealed notably that the proteins (SKIL, SHC, ERK1/2, RAS, PI3K (PIK3CA), SMAD8, ACVR2A/1B SNON, AKT, and SMAD3, from TGF β and (RNF43, SNAIL1 and DVl) for β catenin show high expression in most caner tissues. Our results strongly suggest that these proteins might have the ability to act as potential objects for remedies and provide perception into the molecular basis of cancer.

Highlights

Cancer is considered the second cause of mortality globally; it has been found that many genes mutations are involved in cancer pathogenesis
Our findings revealed notably that the proteins (SKIL, SHC, ERK1/2, RAS, PI3K (PIK3CA), SMAD8, ACVR2A/1B SNON, AKT, and SMAD3, from TGF β and (RNF43, SNAIL1 and DVl) for β catenin show high expression in most caner tissues
As there has been huge research into the proteins that are involved in TGF β & β- catenin pathways, we have utilized data presented in the database in this paper to examine the level of expression for the crucial 53 proteins that are identified to be involved in the activation of these pathways in a distinct group of 45 cancer types

Summary

Introduction

Cancer is considered the second cause of mortality globally; it has been found that many genes mutations are involved in cancer pathogenesis. The two pathways TGF β & β - catenin are model that are integrated in growth, proliferation, persistence, motility, metabolism, and the regulation of immune response. Stimulation of these pathways is an important causes of cancer cell endurance to antitumor remedies. This causes these pathways an essential purpose for discriminating the improvement and progression of this illness. They may play a part as a potential anti-cancer drug (Ortega et al, 2020)

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