Abstract
BackgroundThe peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already. Purpose of our research is to explore the expression profiles and prognostic values of PRDXs in breast cancer (BrCa).MethodsThe transcriptional levels of PDRX family members in primary BrCa tissues and their association with intrinsic subclasses were analyzed using UALCAN database. Then, the genetic alterations of PDRXs were examined by cBioPortal database. Moreover, the prognostic values of PRDXs in BrCa patients were investigated via the Kaplan-Meier plotter.ResultsThe transcriptional levels of most PRDXs family members in BrCa tissues were significantly elevated compared with normal breast tissues. Meanwhile, dysregulated PRDXs expression was associated with intrinsic subclasses of BrCa. Besides, copy number alterations (CNA) of PRDXs positively regulated their mRNA expressions. Furthermore, high mRNA expression of PRDX4/6 was significantly associated with poor overall survival (OS) in BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable OS. Simultaneously, high mRNA expression of PRDX1/2/4/5/6 was significantly associated with shorter relapse-free survival (RFS) in BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable RFS. In addition, the prognostic value of PRDXs in the different clinicopathological features based on intrinsic subclasses and chemotherapeutic treatment of BrCa patients was further assessed in the KM plotter database.ConclusionOur findings systematically elucidate the expression profiles and distinct prognostic values of PRDXs in BrCa, which might provide novel therapeutic targets and potential prognostic biomarkers for BrCa patients.
Highlights
The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already
The highest mRNA expressions of PRDX1/5/6 were found in Epidermal growth factor receptor 2 (HER2)-positive tissues (Fig. 2a, e, f ), and the highest mRNA expressions of PRDX4 were found in triple-negative tissues (Fig. 2d)
1.45, P < 0.001), PRDX4 (HR = 1.54, 95% Confidence interval (CI): 1.38–1.72, P < 0.001), PRDX5 (HR = 1.21, 95% confidence interval (95% CI): 1.04–1.42, P = 0.015) and PRDX6 (HR = 1.20, 95% CI: 1.08–1.34, P < 0.001) were significantly associated with shorter relapse-free survival (RFS) of breast cancer (BrCa) patients, while high mRNA expression of PRDX3 was notably related to favorable RFS of BrCa patients (HR = 0.81, 95% CI: 0.72–0.90, P < 0.001)
Summary
The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already. Purpose of our research is to explore the expression profiles and prognostic values of PRDXs in breast cancer (BrCa). Several researches have suggested that overexpression of PRDXs may play dichotomous role in oncogenesis of tumors, where they could either stimulate the progression of cancers or suppress the development of cancers [5]. An increasing number of studies have observed the preliminary functions and ambiguous prognostic values of PRDXs in cancerous diseases [6,7,8,9]. The expression profiles and prognostic values of PRDXs in BrCa samples are still elusive up to now. Our research aims to explore the differential expression and potential roles of PRDXs in BrCa
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