Abstract
BackgroundCeramide plays an important role in the occurrence and development of tumor. The synthesis of ceramide needs the participation of LASS. Current studies have shown that different LASS family members play different functions in tumors, especially LASS6, has been proved to play a key role in breast cancer, gastric cancer, melanoma and so on, but the research on ovarian cancer is very limited.MethodsBioinformatics web resources, including Oncomine, UALCAN, Kaplan–Meier Plotter and TIMER were used to analyze the expression profile, prognostic value and immune infiltration of LASS6. The related genes of LASS6 in ovarian cancer were mined by Regulome Explorer and LinkedOmics database, and cluster analysis was done by DAVID. The PPI network involving LASS6 was constructed by STRING database. Finally, the correlation between 10 genes and LASS6 was analyzed by GEPIA database, and their prognostic value in ovarian cancer was analyzed by Kaplan–Meier plotter.ResultsThe expression of LASS6 was up-regulated in ovarian cancer, which was related to the progression and poor prognosis of ovarian cancer. Through GO/KEGG cluster analysis, we also found that LASS6 may affect calcium ion channel and its transport pathways. The analysis of regulatory network involved in LASS6 showed that the high mRNAs of 7 key genes were associated with poor prognosis of OS in patients with ovarian cancer, among which DEGS1 was the most significant.ConclusionsLASS6 may play an important role in the regulation of calcium pathway and become a new therapeutic target and potential prognostic marker in ovarian cancer.
Highlights
Ceramide plays an important role in the occurrence and development of tumor
The expression of LASS family genes in cancer In order to study the difference of LASS family gene expression between tumor samples and normal tissues, we used Oncomine database to analyze the mRNA levels of 6 LASS family genes in different tumor types (Fig. 1)
The results showed that the expression of LASS1, LASS5 and LASS6 had an effect on the overall survival (OS) and prognosis of patients with ovarian cancer
Summary
Ceramide plays an important role in the occurrence and development of tumor. Current studies have shown that different LASS family members play different functions in tumors, especially LASS6, has been proved to play a key role in breast cancer, gastric cancer, melanoma and so on, but the research on ovarian cancer is very limited. Ovarian cancer has the highest mortality rate, causing more than 150,000 deaths worldwide every year [19, 24, 48]. The five-year average survival rate of ovarian cancer decreases gradually with the increase of clinical stages. Xing and Yi J Ovarian Res (2021) 14:117 recurrence, which is one of the reasons for the low survival rate of ovarian cancer [1, 20, 31]. We urgently need to find reliable biomarkers to analyze the prognosis of clinical treatment and adjust the treatment strategy
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