Abstract
One new coumarin, dryofracoumarin A (1), and eight known compounds 2–9 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans- and cis-3-(3,4-dimethoxyphen-yl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphen-yl)but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 ± 0.86 μM and 24.14 ± 3.12 μM. These active compounds might be promising lead compounds for the treatment of cancer.
Highlights
Traditional Chinese Medicines (TCMs), are commonly used as representative alternative and complementary medicines for the treatment of cancer in Asian countries [1]
One new coumarin compound 1 was isolated from the 95% ethanol extract of D. fragrans, together with eight known compounds
All compounds were investigated for their anticancer activity in vitro against A549, MCF7
Summary
Traditional Chinese Medicines (TCMs), are commonly used as representative alternative and complementary medicines for the treatment of cancer in Asian countries [1]. Its efficacy is frequently attenuated due to drug resistance and side effects [5], so it is urgent to identify new targets to treat cancer from TCMs. Dryopteris fragrans (L.) Schott (Chinese name: Xiang-Lin-Mao-Jue) is a deciduous perennial herb of the Dryopteris genus, which grows mainly in small communities on the talc slopes of the alpine region and the lava cracks of volcanoes (Figure 1). Dryopteris fragrans (L.) Schott (Chinese name: Xiang-Lin-Mao-Jue) is a deciduous perennial herb of the Dryopteris genus, which grows mainly in small communities on the talc slopes of the alpine region and the lava cracks of volcanoes (Figure 1) It is distributed in many countries, especially in. Compounds with significant cytotoxic activity on A549, MCF7 and HepG2 cells (in vitro lung, breast and liver cancer models) were reported
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
