Abstract
Background: Cardiac arrest (CA) and differentially expressed genes (DEGs) relative to post-CA have attracted the attention of scientist to prevent damages, which threaten patients. In the present study, metabolites relevant to DEGs of post-CA condition investigated via protein-compound interaction to understand the pathological mechanisms in the human body. Materials and Methods: STITCH plug-in integrated into Cytoscape V.3.6.1 was used to detect the most significant interacting compounds relative to DEGs of pig’s brain after 5 minutes’ CA. The genes were obtained from the Gene Expression Omnibus database. The identified elements were considered for further evaluation and validation by literature survey. Result: Findings indicate that biochemical compounds including magnesium, calcium, glucose, glycerol, hydrogen, chloride, sulfate, and estradiol interact with DEGs in the two up- and down-regulated networks. Conclusion: The compounds interacting with DEGs are suitable subjects to analysis for re-regulation of the body after CA.[GMJ.2018;7:e1380]
Highlights
Cardiac arrest (CA) is one of the frequent life-threating situations by which the brain is the most important post affected parts [1, 2]
Meaning that identification of biomarkers related to CA can play a role in prognosis, diagnosis, and treatment approaches, and it is valuable in different states of physiological conditions
On of promising ones is the whole genome study such as array evaluation that could detect some genes with differential expression in this matter [9]. Interaction of these differentially expressed genes (DEGs) with other biochemical reagents such as metabolites could be important to evaluate them as the key important players in cellular functions [10, 11]
Summary
Cardiac arrest (CA) is one of the frequent life-threating situations by which the brain is the most important post affected parts [1, 2]. On of promising ones is the whole genome study such as array evaluation that could detect some genes with differential expression in this matter [9] Interaction of these differentially expressed genes (DEGs) with other biochemical reagents such as metabolites could be important to evaluate them as the key important players in cellular functions [10, 11]. These compounds may have an impaired level in the serum as they are linked to DEGs. In this study, the communicating compounds after identification were assigned for systematic review to evaluate and validate their possible impaired levels in the body. In this study, biochemical reagents linked to DEGs were examined to get a better knowledge of post-CA mechanisms
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