Abstract
This randomized, double-dummy, double-blind study was to observe the therapeutic effects of compound Danshen dripping pill (CDDP) in treating early diabetic retinopathy (DR). All the 57 type 2 diabetes cases in nonproliferative diabetic retinopathy (NPDR) stage were divided into two groups randomly: 28 cases treated with CDDP as the treated group and 29 cases treated with calcium dobesilate as the control group. The best corrected visual acuity (BCVA) in the treated group was significantly improved after treatment when compared to that before treatment (P < 0.05). Mean defect (MD) of visual field, hemorrhage area of the fundus, microaneurysm number, fluorescent leakage area, and capillary nonperfusion area evaluated by visual field, fundus photography, and fundus fluorescein angiography in the treated group had the same results as BCVA. However, there was no statistical difference in each index between the two groups. No obvious adverse events with clinical significance occurred. Our present study showed that CDDP has a similar improvement and safety to calcium dobesilate for NPDR. In future DR treatments, CDDP may function as the auxiliary drug.
Highlights
Diabetic retinopathy (DR) is a common microvascular complication of diabetes
One-quarter of DR patients develop severe visual impairment [2], which is mainly attributed to diabetic macular edema and proliferative diabetic retinopathy (PDR) [3]
For nonproliferative diabetic retinopathy (NPDR), laser photocoagulation [5] and surgical treatment [6] are the most commonly used therapeutic methods, but, for pathological changes with the retina or the macular hemorrhage and edema, antivascular endothelial growth factor (VEGF) drugs are used [7] in clinical treatment
Summary
Diabetic retinopathy (DR) is a common microvascular complication of diabetes. DR is characterized by microaneurysm, exudation, neovascularization, vitreous hemorrhage, and so on in the retinal microvasculature, which can cause different degrees of vision loss or irreversible blindness. For nonproliferative diabetic retinopathy (NPDR), laser photocoagulation [5] and surgical treatment [6] are the most commonly used therapeutic methods, but, for pathological changes with the retina or the macular hemorrhage and edema, antivascular endothelial growth factor (VEGF) drugs are used [7] in clinical treatment. These therapeutic methods cannot reverse the existing retinal damage. Chinese herbal medicines are alternative therapeutics that have been used for thousands of years in China These medicines are acceptable in the world. These medicines should be explored and used for treating DR
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