Abstract
A multi-component acrylate-based copolymer system especially designed for application as ocular lenses is developed through free-radical, bulk polymerization of a system containing hydroxyethyl methacrylate, methyl methacrylate, triethylene glycol dimethacrylate, dimethyl itaconate, 3-(trimethoxysilyl) propylmethacrylate, Polyhedraloligomeric silsesquioxane-acrylate (POSS-acrylate) and AIBN as an initiator. The progress of the reaction was monitored by Fourier transform infrared spectroscopy (FTIR). The effect of increasing concentration of the components on the hardness of the synthesized lenses was measured by Shore Durometer before and after immersion in PBS solutions. Extraction test method was performed to analyze the biocompatibility of the fabricated lenses. In this research the Taguchi method was employed to achieve the optimal hardness property which plays a critical role in final application of the lens materials. The Taguchi trial for ocular lens hardness was configured in an L16 orthogonal array, by five control factors, each with four level settings. The results showed that 3-(trimethoxysilyl) propyl methacrylate decreases and 2-hydroxyethylmethacrylate increases, polyhedraloligomeric silsesquioxane with a cage-like structure, methyl methacrylate and dimethyl itaconate increase the hardness. Proliferation and growth of the cells showed that there is no toxic substance extracted from the lenses which can interfere with the cell growth.
Highlights
In the past few years, a majority of 60% of worldwide population reported to use visual aids such as glasses or contact lenses which would rise steadily in the future (Morgan et al 2009; Jan-Willem Bruggink et al 2013).a market over tens of billions of dollars per year would be predicted for this global market in ophthalmic industry (Nichols 2009).As a brief history, ocular lenses have developed by the earliest ideas from Leonardo da Vinci to the present day.Firstly, they were made of glasses and lens materials gradually became friendlier by invention of hydrogels which were more comfortable and adjustable
A multi-component acrylate-based copolymer system especially designed for application as ocular lenses is developed through free-radical, bulk polymerization of a system containing hydroxyethyl methacrylate, methyl methacrylate, triethylene glycol dimethacrylate, dimethyl itaconate, 3-(trimethoxysilyl) propylmethacrylate, Polyhedraloligomeric silsesquioxane-acrylate (POSS-acrylate) and AIBN as an initiator
In this research the Taguchi method was employed to achieve the optimal hardness property which plays a critical role in final application of the lens materials
Summary
In the past few years, a majority of 60% of worldwide population reported to use visual aids such as glasses or contact lenses which would rise steadily in the future (Morgan et al 2009; Jan-Willem Bruggink et al 2013).a market over tens of billions of dollars per year would be predicted for this global market in ophthalmic industry (Nichols 2009).As a brief history, ocular lenses have developed by the earliest ideas from Leonardo da Vinci to the present day.Firstly, they were made of glasses and lens materials gradually became friendlier by invention of hydrogels which were more comfortable and adjustable. In the past few years, a majority of 60% of worldwide population reported to use visual aids such as glasses or contact lenses which would rise steadily in the future (Morgan et al 2009; Jan-Willem Bruggink et al 2013). Ocular lenses have developed by the earliest ideas from Leonardo da Vinci to the present day. They were made of glasses and lens materials gradually became friendlier by invention of hydrogels which were more comfortable and adjustable. In the twenty-first century, silicone hydrogels allowed more than 90% of available O2 to reach the eyes and allowed the lenses to be thinner (Gasson and Moriss 2003)
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