COMPOSITION, STRUCTURE AND PHARMACOLOGICAL ACTIVITY OF HETEROMETALLIC BIS(CITRATO)GERMANATE(STANNATE) COMPLEXES

Abstract

This review article summarizes the results of the study of the composition, structure and pharmacological activity of related different-metal cation-anionic complexes with bis(citrato) germanate(stannate) anion and hexaquacation of the second metal M(H 2 O) 6 ][Ge(HCit) 2 ]·nH 2 O and [M(H 2 O) 6 ][Sn(HCit) 2 ]·nH 2 O, де М = Mg, Mn, Fe, Co, Ni, Cu, Zn, n=2-4. The inspire for this study were the features of citric acid as an intermediate product of the metabolic cycle of tricarboxylic acids, which plays a major role in the system of biochemical reactions of cellular respiration. Authors defined the conditions for the formation of heterometallic complexes in the systems GeО 2 (GeCl 4 , SnCl 4 ) – citric acid (H 4 Cit) – M(CH 3 COO) 2 (FeSO 4 , AgNO 3 ) – H 2 O (М=Mg 2+ , Mn 2+ , Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ ), obtained their complete physicochemical characteristics, and also established their molecular and crystalline structures. All compounds have low toxicity. They were proved to have a wide range of pharmacological activity (neurotropic, antistaphylococcal, antiviral, antihypoxic, cerebroprotective. The level and characteristics of a particular type of pharmacological action of the studied drugs is determined by the metal ions – parts of the complex cations and anions, as well as their synergetic effect. The relationship between the composition, structure and pharmacological activity of the complexes was established. The novelty of the approach allowed to obtain supramolecular salts with the structural blocks of opposite charges – complex cations and anions of different metals. Therefore, they do not compete with each other for binding to biosubstrates, but potentiate or enhance each other’s action.