Abstract
Twenty three allophenic mice, produced by the aggregation of two 8-cell embryos, were examined by cytotoxicity testing for the proportions of parental cell types in their total splenic lymphocyte populations. Eleven (CBA × CBA/H-T6) ↔ C57BL/6 mice and six (CBA × CBA/H-T6) ↔ DBA/1 mice were assessed for the composition of their splenic T cells by culturing the cells in phytohemagglutinin, followed by identification of the T6 chromosomal marker in mitotic spreads. Six CBA ↔ DBA/1 mice were assessed for their splenic T cell composition by isolating their T cells on a nylon-wool column. The 23 mice showed an excellent statistical correlation of their total spleen cell composition with their splenic T-cell composition. However, there are some individual mice in which these two parameters are not correlated.
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