Abstract
Increased levels of soluble fibrin were found in plasma samples of patients with pre-eclampsia as measured by affinity chromatography on fibrinogen-sepharose 4B. Isolated fibrin had intact α, β and γ chains but did not show γ dimer. By comparing levels of soluble fibrin and soluble fibrin complexes, and also by estimation of the MW of the soluble complexes using agarose gel filtration, soluble fibrin complexes were shown to be composed of noncrosslinked fibrin-fibrinogen dimers.
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