Abstract
Long chain polyunsaturated fatty acids (LC-PUFAs) are hypothesized to play an important role in attention deficit/hyperactivity disorder (ADHD). This study evaluated LC-PUFAs composition in different encephalic regions by gas chromatography and its association with behavior on the attentional set-shifting task, open field test and the Morris water maze of spontaneous hypertensive rat (SHR)—a genetic animal model of ADHD. In behavioral tests, the SHRs exhibited deficiencies in attentional set-shifting, autonomic activities and spatial learning and memory. In all the studied encephalic regions, we observed higher concentration of docosahexaenoic acid (DHA) and arachidonic acid (AA) and higher AA/DHA ratio in the SHRs compared with the Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats (p<0.01), which was associated with abnormal behavior in the SHRs. This study provided an appropriate animal model for study on the relationship between LC-PUFAs and ADHD. Our results prove abnormal neurobehaviour associated with imbalance of AA/DHA ratio and highlights the significance of normal AA/DHA ratio in behavior.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
