Abstract
Musculoskeletal disorders (MSDs) are one of the most pressing medical issues we face today, due to the modern, sedentary lifestyle of humankind. Because of the serious side effects of nonsteroidal anti-inflammatory drugs, searching for other remedies and selecting the best medicinal form of the drug still remains one of the major challenges in medicine.The aim of this research was the development of a gel for the treatment of Musculoskeletal pathologies. The proteolytic enzyme bromelain from the stems of the pineapple plant (Ananas comosus) was selected as the main active substance, due to its strong anti-inflammatory and analgesic properties. Its chemical modification with dextran aldehyde was performed to reduce its allergic effect and to increase stability. Statistical characteristics of the method for determining the proteolytic activity of bromelain were processed. A mixture of polyethylene glycol-1500 and polyethylene glycol-4000 was selected as the base of the gel. Stem bromelain and modified bromelain gels were prepared. The proteolytic activities of the developed gels were determined for 6 months every 3 months. The results demonstrated that proteolytic activities were maintained over the studied period of time, indicating that the gels are stable.
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