Abstract
Gangliosides were identified as constituents of milk and mammary gland of cows. On a sialic acid basis, the average concentrations of gangliosides in mammary gland and milk were 88.4 and 5.6 nmoles/g wet weight. Nearly 90% of the milk gangliosides were contained in milk fat globule membrane. The same six chromatographically distinguishable gangliosides were found in mammary gland and the fat globule membrane. Structures of three of the gangliosides were shown to be ceramide-glucose-galactose-sialic acid, ceramide- glucose- galactose-( sialic acid)- N- acetyl- galactosamine, and ceramide- glucose- galactose- sialic acid- sialic acid. The latter was the most abundant ganglioside, accounting for more than 50% of the lipid-bound sialic acid in mammary gland and milk. Both N-acetyl- and - N-glycolylneuraminic acids were found in mammary ganglioside fractions. Fatty acids with even carbon numbers from C 14 to C 24 were contained in gangliosides. Appreciable amounts of n-tricosanoic acid were also present. Mammary gland had all glycosyltransferases involved in synthesis of N acetylneuraminyl 2 -galactosylglucosyl ceramide ( GD 3) starting with ceramide.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
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