Abstract
The complexes of Ephedrine with Nickel, Zinc and Cadmium ions have been investigated spectrophotometricalfy using the method of corresponding solutions [I-3] and pH-metrically using Irving and Rossoti technique [4] Two compositions were observed spectrophotometrically 1 : 1 and 2: 1 (L: M) for concentration of metal ions (0.5 x 10-3 M and 1 x 10-3 M) hile the first composition only predominate at concentration of metal ions (1.5 x 10-3 M and 2 x 10-3 M ). The stability of complexes show that complexes of Ni2+ are more stable than that of Zn2+ an Cd2+, Moreover, the composition and stabilities of complexes were studied pHmetrically in aqueous medium at 0.1 M NaCl and two different temperatures 30°C and 40°C; hence the value of the free energy change (ΔG°), the enthalpy (ΔH°) and the entropy (ΔS°) were calculated at 30°C. Beside the role of Ephedrine as chelating agent to toxic elements, the complexometric method was used for the determination of Ephedrine in its pure form and in tablets.
Highlights
Ephedrine hydrochloride may be obtained from the plant Ephedra which is a kind of alkaloids or prepared synthetically. It is one of the most important drugs used primarily for asthma and other respiratory conditions [5] and for treating circulatory collapse during surgery and as bronchodilator [6].Theaim of the study of Ephedrine chelation with the three metal ions cited ( ~ i 2 +~, n 2 a+nd ~ d * + t)aken as toxic elements; is to remove most of the unwanted metal ions in biological fluids; since it is known that the excess of any element, whether essential or not is harmful
Several methods have been reported for the determination of Ephedrine hydrochloride spectrophotometrically [ I2-151, by capillary electrophoresis [16,17) potentiometry [I8,191 and by chromatographic methods [20-221
From these figures it was shown that the lowest free ligand concentration was that for nickel ion complexes indicating that this metal ion had more ability to form
Summary
Ephedrine hydrochloride may be obtained from the plant Ephedra which is a kind of alkaloids or prepared synthetically. Several methods have been reported for the determination of Ephedrine hydrochloride spectrophotometrically [ I2-151, by capillary electrophoresis [16,17) potentiometry [I8,191 and by chromatographic methods [20-221. None of these methods utilize the above metal ions for the determination of Ephedrine and studying the composition and stabilities of its complexes. The prepared metal ion solutions were standardized against EDTA solution Aliquot of 5 ml was diluted to 25 ml after adding nickel ion as reagent, adjusting to the convenient pH, adding 2.5ml NaCl and measuring at274nm
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
