Abstract
The controlled release of drugs represents an interesting procedure applied in the minimization of side effects and in the therapeutic action of pharmacological molecules. With the aim of measuring the kinetics of release of aspirin dispersed in composite of an enteric polymer (Eudragit L-100) in the presence/absence of magnetic particles, we have considered the measurement of fluorescence as a convenient tool. The results indicate that rate of release and amount of dispersed drug in solution varies directly with the concentration of magnetite in the composite, as a consequence of strong interaction between components of microparticles.
Highlights
Aspirin is a non-steroidal anti-inflammatory drug with analgesic properties [1], applied in the secondary prevention of atherosclerosis [2, 3]
In the mixed system, the control of release process is provided by the use of Eudragit L100, a polymeric matrix composed by a hydrophilic monomeric unit and a hydrophobic part
The concentration of released aspirin in the solution was determined from a calibration curve obtained in the complete absence of other components
Summary
Aspirin is a non-steroidal anti-inflammatory drug with analgesic properties [1], applied in the secondary prevention of atherosclerosis [2, 3]. The optimal dose of aspirin depends on the clinical conditions of each patient, if considering the risk of side effects (as a consequence of continued administration of this drug) such as renal function deterioration. In the mixed system (drug/ magnetite/ enteric polymer), the control of release process is provided by the use of Eudragit L100, a polymeric matrix composed by a hydrophilic monomeric unit (metacrylic acid) and a hydrophobic part (methyl metacrylate). This process is dominated by the ionization degree of carboxylic group, which depends on the pH of media and affects the polymeric conformation [15, 16]
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