Composites based on graphite oxide and zirconium phthalocyanines with aromatic amino acids as photoactive materials

Yuriy Gerasymchuk,Izabela Korona-Glowniak,Leili Tahershamsi,Anna Lukowiak,Anna Malm,Viktor Chernii,Iryna Tretyakova,Robert Tomala,Dominika Piatek,Anna Wedzynska,Barbara Rajtar

doi:10.1007/s11696-021-01731-7

Yuriy Gerasymchuk, Izabela Korona-Glowniak + Show 9 more

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https://doi.org/10.1007/s11696-021-01731-7

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Abstract

This article is a part of a scientific project focused on obtaining a new type of composite materials that are characterized by singlet oxygen generation upon irradiation with red light, which can be used as antibacterial agents. The composite material is nanoscale graphite oxide (GO) particles covalently bonded to an axially substituted zirconium phthalocyanine complex. For this purpose, two phthalocyanine zirconium complexes, axially mono-substituted with 4-aminosalicylic or 4-aminophthalic acids, were prepared and measured in terms of structure, morphology, and spectroscopic properties. The zirconium phthalocyanines are photosensitizers, and the axial ligands are bridging links connecting the complexes to the GO carrier (due to their terminal amino groups and carboxyl groups, respectively). The axial ligand in zirconium phthalocyanine complexes has a strong influence on the stability and optical properties of composite materials and, consequently, on reactive oxygen species (ROS) generation. In this paper, the effect of composite components (4-aminophthalato or 4-aminosalicylato substituted zirconium phthalocyanine complex as a photosensitizer and graphite oxide as a carrier and modulator of the action of active components) on ROS generation for potential antibacterial use is discussed.

Highlights

The acquired bacterial resistance to antibiotics is one of the biggest problems of medicine (Zaman et al 2017; Aslam et al 2018; Nathan 2020; Frieri et al 2017)
We have proposed new composite materials based on graphite oxide as a carrier modified with photosensitizer (axially substituted phthalocyanine Zr(IV)) and optionally with nanometric silver (Gerasymchuk et al 2016)
Axial ligands in the investigated complexes should contain terminal amino groups that allow covalent linking with the carrier graphite oxide which has various terminal oxygen containing groups

Summary

Introduction

The acquired bacterial resistance to antibiotics is one of the biggest problems of medicine (Zaman et al 2017; Aslam et al 2018; Nathan 2020; Frieri et al 2017). 2 V.I. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., Kyiv 03‐142, Ukraine. Vernadskii Institute of General and Inorganic Chemistry, 32/34 Palladin Ave., Kyiv 03‐142, Ukraine To solve this problem, we have proposed new composite materials based on graphite oxide as a carrier modified with photosensitizer (axially substituted phthalocyanine Zr(IV)) and optionally with nanometric silver (Gerasymchuk et al 2016). (1) Graphite oxide—a nanosized carrier and catalyst of silver nanoparticles (Ag-NPs) formation, which shows antibacterial properties and enhances the antimicrobial activity of silver (Gerasymchuk et al 2017; Lukowiak et al 2019; Tahershamsi et al 2020; Kędziora et al 2013; Saladino et al 2020);.

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