Abstract
Composite SCCmec element in single-locus variant (ST217) of epidemic MRSA-15 clone.
Highlights
2. de Almeida LM, Lincopan N, Araújo MR, Mamizuka EM
To the Editor: Since early epidemiologic studies of methicillinresistant Staphylococcus aureus (MRSA) were published, it has been clear that the majority of nosocomial MRSA infections worldwide are caused by isolates derived from a few highly epidemic MRSA (EMRSA) clones. These are thought to have emerged through acquisition of the staphylococcal cassette chromosome mec (SCCmec) element by successful methicillin-susceptible S. aureus strains, within 5 major lineages or clonal complexes (CCs) including CC22 [1]
The composite SCCmec organization we detected in strain Lu1, featuring 2 ccr complexes, is similar to that described in 2 isolates that belong to different genetic lineages: 1 (ST100, CC5), later designated ZH47 [5,9], was identified in a sample from an inpatient in Switzerland [7]; and the other (ST59, CC59, community-associated MRSA) from a pediatric patient in Taiwan [10]
Summary
2. de Almeida LM, Lincopan N, Araújo MR, Mamizuka EM. Dissemination of the linezolid-resistant Staphylococcus epidermidis clone ST2 exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary-care hospital, Brazil. These are thought to have emerged through acquisition of the staphylococcal cassette chromosome mec (SCCmec) element by successful methicillin-susceptible S. aureus strains, within 5 major lineages or clonal complexes (CCs) including CC22 [1]. Investigation of the genetic background of the strain isolated from the child’s specimen, designated as Lu1, led to its assignment as ST217, a single-locus variant of EMRSA-15 within the same CC, CC22 (http:// saureus.mlst.net), agr group I, and spa type t965.
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