Abstract
The aim of this study was to evaluate the healing of an osteochondral fragment created in the distal sheep femur in response to fixation with a biodegradable polylactide/hydroxylapatite composite screw. Poly(L-lactide) screws were used for comparison. At follow-up times of 4 and 8 weeks, the specimens were examined with standard radiography and computed tomography, as well as with macro- and micro-histomorphometry. The intact contralateral femur served as a control. Only minimal signs of degradation of the polymer could be seen in the histologic specimens. At 8 weeks, nearly all osteotomies had healed completely and an association between implant type and delayed osteotomy healing was found. The width of the repair tissue at the tissue–implant interface was 250 ± 48 μm, representing a clear transition zone of newly formed trabecular bone separating the implant from the surrounding plexiform bone. This study showed that large polylactide implants which are buffered with hydroxylapatite show benign tissue responses and good implant osteointegration. The osteotomy healing in a weight-bearing osteochondral fragment model in sheep utilizing a composite polylactide/hydroxylapatite screw was equivalent to a similar polylactide screw implant, indicating that hydroxylapatite-buffered screw implants could be used for similar indications in current clinical use.
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