Composite material immobilized in 3D-printed support, an economical approach for electrochemical sensing of nimesulide

Abstract

This work aimed to build a disposable electrode, cheap, and robust, with a maximum manufacturing value of US$ 0.02 per sensor, whose basic structure is a composite material (CM) immobilized on 3D support of acrylonitrile butadiene styrene (ABS), to the determination of Nimesulide (NIM) in different samples. The surface characterization of the electrodes was made by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The electrochemical response for NIM obtained was compared with a commercial Glassy Carbon electrode (GCE), where a 70 % increase in the analytical response was observed. The sensor was applied for the quantification of NIM by the square wave voltammetry (SWV) method in pharmaceutical formulations, tap water, synthetic urine, and breast milk. The optimized method presented a satisfactory linear range of 10 to 50 µmol/L, with a simple sample treatment, good precision (RSD < 3.38 %), and excellent detectability (limit of detection 0.018 µmol/L). Samples were spiked at three concentration levels to evaluate the accuracy of the method, obtaining recovery values from 96.2 to 112.8 %. Thus, the disposable proposed device proves to be a promising analytical tool for routine analysis of NIM in different samples with a minimum sample preparation step (simple dilution).