Composite material based on hydroxyapatite and multi-walled carbon nanotubes filled by iron: Preparation, properties and drug release ability

Abstract

The novel bioactive composite material based on hydroxyapatite and multi-walled carbon nanotubes filled by iron was synthesized by the “wet chemistry” method and characterized in detail by various experimental techniques including the X-ray diffraction, Fourier transform infrared and energy-dispersive X-ray fluorescence spectroscopy, thermogravimetric and differential thermal analysis. The swelling behaviour was quantified by measuring the changes in sample weight as a function of sample immersion time in a phosphate buffered saline (PBS). Bioactivity test was carried out by soaking the samples in PBS. The material composition influence on the model drug release was studied using the high-performance liquid chromatography method. Finally, the mechanical properties (maximal relative deformation, strength and Young's modulus) of the samples under loading were investigated too. The findings clear demonstrate the possibility of application of the created composite material in bioengineering of bone tissue to fill bone defects of various geometries with the function of prolonged release of the drug. It is assumed that this composite material can be used in 3D modeling of areas of bone tissue that have to bear a mechanical load.