Abstract
New molecular biomarkers that could have an independent prognostic value in endometrial cancer are currently under investigation. Recently, it was suggested that genetic changes in the Notch signaling pathway could be associated with the development of endometrial carcinoma. This study aimed to determine the expression of the Notch signaling pathway components in tumour and adjacent normal uterine tissue and to evaluate their importance for the survival of uterine cancer patients. The present study was performed on uterine body samples collected from 109 patients and paired adjacent noncancerous endometrial tissue samples. Kaplan–Meier curves and Cox regression were used for survival analyses. Expression alterations of NOTCH2, NOTCH3, NOTCH4, JAG2, and HES1 were evaluated as independent and significant prognostic factors for uterine cancer patients.
Highlights
Uterine cancer is the sixth most common cancer among women worldwide, counting about 417 000 new cases and 97 000 deaths in 2020 [1]
Uterine Patient’s Survival Rate Depending on the Expression of the Notch Signaling Pathway Components. e study evaluated the potential influence of the investigated Notch signaling pathway components on survival rates in patients with uterine cancer (Figure 2). e analysis of the obtained data showed a statistically significant association between the survival rate of uterine cancer patients and the expression of NOTCH2 gene (Figure 2(a))
Decreased NOTCH3 gene expression had shown a trend toward better overall survival rates (p 0.08) (Figure 2(b))
Summary
Uterine cancer is the sixth most common cancer among women worldwide, counting about 417 000 new cases and 97 000 deaths in 2020 [1]. It is an actual problem in Lithuania since approximately 600–700 cases of uterine cancer are diagnosed in Lithuania every year. It is the third most common malignancy in women after skin (except melanoma) and breast cancer and leading cancer among gynecological cancers in Lithuania [2]. Incidence rates of uterine cancer are increasing globally, primarily because of increased obesity, a significant risk factor for this disease.
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