Abstract

Component-resolved diagnosis (CRD) has improved in the last years due to the production of standardized testing materials such as purified natural allergens and recombinant proteins, produced by techniques of genetic engineering. CRD has several advantages, such as the ability to identify markers of genuine, primary sensitization, but also to indicate cross-reactivity, an improved analytical sensitivity of the assay when the allergen molecules are of low abundance or missing in the extract, avoidance of exposure to risk- or severity-associated molecules, and also the evaluation of allergen-specific immunotherapy indications. The main disadvantage or limitation of this method is the fact that the vast information provided by molecular allergy needs a structured approach in order to be adequately interpreted. The article below presents the utility of component-resolved diagnosis in food allergies, as well as the molecular allergens from the main food allergen sources.

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