Abstract
Introduction: The most common cause of the spontaneous Cushing syndrome is Cushing Disease (CD, 60–70% of Cushing syndrome patients). CD results from supraphysiologic levels of adrenocorticotropic hormone (ACTH) secreted by a pituitary corticotroph adenoma. The effects of elevated serum cortisol are manifold and poorly tolerated, and transsphenoidal pituitary surgery is the standard of treatment. The goals of surgery are to normalize serum ACTH levels, to restore a normal pituitary–adrenal axis, and eventually to reverse the peripheral manifestations and comorbidities of steroid excess. Reported complications related to transsphenoidal surgery for CD are rare, but it can be serious. We describe the complications of CD patients treated with endonasal endoscopic transsphenoidal surgery.
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