Abstract
COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.
Highlights
COVID-19 was one of the most concerning issues in 2020
The relevant articles were retrieved from the Web of Science core collection database according to the indexes COVID-19 and complication or sequelae on December 30, 2020
We identified research trends and predicted evolutionary directions in terms of high-frequency keywords on CiteSpace
Summary
COVID-19 was one of the most concerning issues in 2020. Coronavirus threatens the life and health of humans [1]. No country around the world has been completely spared. Humans have not truly controlled the spread of 2019-nCoV, and due to the alteration in climate, a second epidemic has appeared. According to the data of the World Health Organization (WHO), the global number of COVID-19 cases has reached to over 130 million, with no sign of weakening. People infected with 2019-nCoV will have symptoms of varying degrees ranging from a fever or a slight cough to pneumonia and even death [3]. Most patients are asymptomatic or have mild cases, and even patients with more severe symptoms can recover with the help of medical treatment
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