Abstract
Clinical sciences are based on several implicit and explicit concepts, assumptions, and beliefs. The current discourse on clinical medicine is dominated by a mechanistic, deterministic, and reductionist world view and has much to gain by embracing the concepts in complexity science (CS). This article sets out to achieve 3 objectives: describe the evolution of models or frameworks used in clinical medicine, outline the application of CS to conceptualize the human body in health and disease, and briefly explore how CS sheds light on our understanding of clinical conditions, using severe sepsis as an example.
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