Abstract

QT and RR intervals’ fluctuations are implicated in the development of malignant arrhythmias. Recent research has quantified repolarization lability using stochastic and linear methods. However, QT-RR intervals are nonlinearly coupled. To this end, QT and RR intervals were extracted from twenty four patients with acute myocardial infarction (AMI) and 13 controls, and a measure of local dimensional complexity (pointwise correlation dimension, PD2) was calculated. PD2 of QT intervals was significantly higher for the patients than for controls (4.83 ± 0.81 versus 3.40 ± 0.76, P = .0001), and vice versa for RR intervals (2.51 ± 0.62 versus 2.91 ± 0.42, P = .028). The RR and QT measures of complexity were highly correlated only among controls (r = 0.769, P = .0021). Our results support the presence of autonomic abnormalities during infarction and might complement existing tools for assessment of increased risk for sudden death after AMI.

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