Abstract
We have read with interest the review ‘A fresh view on lymph node organogenesis’ in the October issue, by Onder and Ludewig [ 1 Onder L. Ludewig B. A fresh view on lymph node organogenesis. Trends Immunol. 2018; 39: 775-787 Abstract Full Text Full Text PDF PubMed Scopus (38) Google Scholar ]. By deconstructing the current two-cell model of embryonic lymph node development in mice, they placed lymphatic endothelial cells (LECs) as key initiators and regulators of lymph node formation. We agree that a more prominent role for LECs within this model is valid; however, we posit that the proposed latter model, in which LECs determine location and control of lymph node initiation, is not supported by the literature and needs reconsideration. A Fresh View on Lymph Node OrganogenesisOnder et al.Trends in ImmunologyAugust 24, 2018In BriefLymph nodes (LNs) are strategically positioned outposts of the immune system that underpin regional immune surveillance. The current model describing LN formation in mice is based on a two cell-type interaction scheme with lymphoid tissue inducer cells regulating the activation of mesenchymal lymphoid tissue organizer cells. We highlight here the key role of lymphatic endothelial cells during the initiation of LN formation. The involvement of lymphatic endothelial cells as an additional organizer cell type in LN organogenesis unveils multiple control levels that govern the generation of lymphoid organs. Full-Text PDF Redefining the Nature of Lymphoid Tissue Organizer Cells: Response to ‘Complexity of Lymphoid Tissue Organizers’ by Koning and MebiusOnder et al.Trends in ImmunologyNovember 2, 2018In BriefWe very much appreciate the interest of Drs Koning and Mebius in our work and their comments on the amended model of lymph node organogenesis summarized in our article ‘A fresh view on lymph node organogenesis’ [1]. The ongoing debate on the nature and complexity of lymphoid tissue organizer cells started 5 years ago at the Third Lymphoid Tissue Meeting in Rotterdam when we first presented our finding that lymphotoxin-β receptor signaling in endothelial cells was crucial for lymph node formation [2]. Full-Text PDF
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