Complexes of Cu(II) with α-[(ethylamino)methyl]-3-hydroxy, benzenemethanol (Effortil). Crystal structure of the mononuclear Cu(II) complex with Effortil

Abstract

The complexation processes between Cu(II) and the antihypotension drug Effortil (HEff) at different reaction conditions lead to the formation of two types of complex — a mononuclear violet one, CuEff 2·2CH 3OH, and the binuclear green Cu 2Eff 2Cl 2. Monocrystals of the mononuclear CuEff 2·2CH 3OH complex were isolated and their structure determined by X-ray diffraction. Copper is coordinated through O − and N of OH and NH groups from the ligands in a perfectly flat tetragon. The crystal structure also includes two solvent CH 3OH molecules per CuEff 2 unit. The CuEff 2 fragments are linked by hydrogen bonds. The binuclear Cu 2Eff 2Cl 2 complex was characterized using electronic and IR spectra, EPR, magnetochemical, calorimetric, thermogravimetric methods and elemental analysis. The complex contains bidentately bound monoanionic ligands and chloride ions. Each Cu atom is coordinated with NH, and bridged by the deprotonated OH group of Effortil with the second Cu center. The chloride ions are coordinated with copper as terminal ligands.