Abstract
The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: Cl (C1), •H2O (C2) and (NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications. Keywords: 1-(o-tolyl)biguanide, a-ketoglutaric acid, copper complexes, antibacterial activity, celule HeLa, antifungal activity
Highlights
Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells
Given the biochemical role of copper and the biological properties of á-ketoglutaric acid and 1- (o-tolyl) biguanide, we have proposed to synthesize and characterize new complex combinations of Cu (II) with these ligands
Antimicrobial and antifungal activity Testing ligands and complexes on Staphylococcus aureus ATCC 25923 it has been found that the best antimicrobial activity had C1 and C3 with a MIC of 0.3125 mg/mL
Summary
Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. (o-tolyl) biguanide (TB) ligands complexes are: [Cu(TB)(HA)]Cl have (C1), Given the biochemical role of copper and the biological properties of á-ketoglutaric acid and 1- (o-tolyl) biguanide, we have proposed to synthesize and characterize new complex combinations of Cu (II) with these ligands.
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