Complexes of 1-thia-4,7,10-triazacyclododecane ([12]aneN 3S) : Synthesis, structure and stability constants

Abstract

The 12-membered macrocyclic ligand 1-thia-4,7,10-triazacyclododecane ([12]aneN 3S) has been synthesised, although upon crystallization from acetonitrile a product in which carbon dioxide had added to one secondary amine in the macrocyclic ring (H[12]aneN 3S–CO 2·H 2O) was isolated and subsequently characterised by X-ray crystallography. The protonation constants for [12]aneN 3S and stability constants with Zn(II), Pb(II), Cd(II) and Cu(II) have been determined either potentiometrically or spectrophotometrically in aqueous solution, and compared with those measured or reported for the ligands 1-oxa-4,7,10-triazacyclododecane ([12]aneN 3O) and 1,4,7,10-tetraazacyclododecane ([12]aneN 4). The magnitudes of the stability constants are consistent with trends observed previously for macrocyclic ligands as secondary amine donors are replaced with oxygen and thioether donors although the stability constant for the [Hg([12]aneN 4)] 2+ complex has been estimated from an NMR experiment to be at least three orders of magnitude larger than reported previously. Zinc(II), mercury(II), lead(II), copper(II) and nickel(II) complexes of [12]aneN 3S have been isolated and characterised by X-ray crystallography. In the case of copper(II), two complexes [Cu([12]aneN 3S)(H 2O)](ClO 4) 2 and [Cu 2([12]aneN 3S) 2(OH) 2](ClO 4) 2 were isolated, depending on the conditions employed. Molecular mechanics calculations have been employed to investigate the relative metal ion size preferences of the [3333], asym-[2424] and sym-[2424] conformation isomers. The calculations predict that the asym-[2424] conformer is most stable for M–N bond lengths in the range 2.00–2.25 Å whilst for the larger metal ions the [3333] conformer is dominant. The disorder seen in the structure of the [Zn([12]aneN 3S)(NO 3)] + complex is also explained by the calculations.