Abstract

This chapter discusses complexes and complexities of the citric acid cycle (CAC) in Escherichia coli . The CAC consists of a series of enzyme-catalyzed reactions that brings about the total oxidation of acetyl units, derived as acetyl-CoA from pyruvate and other metabolites. In the facultative bacterium Escherichia coli , it is an inducible pathway that is fully induced only under conditions that make the greatest demands on its dual anabolic and catabolic functions. Thus, the CAC is highly expressed during aerobic growth in minimal media with a nonfermentable substrate or with C-limiting concentrations of a fermentable substrate. The chapter focuses on several aspects of the CAC that have arisen from genetic and molecular genetic studies with E. coli .

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