Abstract
This study focuses on the inclusion complex of ephedrine with β-CD. The association of β-CD and ephedrine has been examined using1H NMR and circular dichroism. The systematic shifts of the proton resonances of the phenyl moiety of ephedrine and that of the protons located inside the β-CD cavity, provide evidence of intracavity inclusion. Two-dimensional ROESY show preferential localization of ephedrine in close proximity with protons located inside the β-CD cavity. The systematic variation of circular dichroism spectra with increasing concentration of β-CD is used to estimate the apparent formation constant.
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