Abstract
Complex formation of α- and β-cyclodextrins with biologically active nicotinamide and Nhydroxymethylnicotinamide (nicodine) was studied by calorimetry and 1H NMR spectroscopy. Cyclodextrins showed a weak complexing ability toward nicotinamide and nicodine: 1: 1 enthalpy-stabilized host-guest complexes were formed in aqueous solution at 298.15 K. Nicotinamide and nicodine molecules appeared inside the macrocycle cavity of cyclodextrins, but interaction between their polar side-chain groups with the outer surface of cyclodextrins cannot be ruled out. Thermodynamic parameters of the complexation process were calculated, and a mechanism was proposed for the observed interaction. The results were compared with those obtained previously for the complexation of cyclodextrins with nicotinic acid.
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