Abstract
Complexations of R(+) and RS(+/−)aminoglutethimide (AGT), the drug used in a treatment of breast and prostate cancer with native and modified cyclodextrins (α-CD, β-CD, γ-CD, 2,6-di-O-methyl-β-CD (DM-β-CD), 2,3,6-tri-O-methyl-β-CD (TM-β-CD) and carboxymethyl-β-CD (CM-β-CD)) were studied. The stability constants were determined with UV–Vis spectrophotometric method at pH 9.0. The NMR data obtained for TM-β-CD suggest that the complexation of AGT is possible from both sides of CD molecule. This was confirmed by molecular dynamic simulations. Copyright © 2009 John Wiley & Sons, Ltd.
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