Complexation of adamantyl derivatives by a β–cyclodextrin dimer.

Luciano Galantini,Aida Jover,Alvaro Antelo,Mercedes Alvarez Alcalde,Francisco Meijide,José Vázquez Tato

doi:10.3390/ecsoc-13-00258

Abstract

The binding constants, standard molar enthalpy, Gibbs free energy, and entropy changes were determined for the formation of complexes between adamantyl derivatives and a β-cyclodextrin dimer. It is concluded that, within experimental error, the two cyclodextrin residues in the dimer behave independent to each other when complexing the adamantyl derivatives.

Highlights

Supramolecular chemistry is mainly focused in designing new molecules which, after processes as recognition and assembling, form new identities denoted complexes, supramolecular assemblies, etc.[1]
One well known example of a supramolecular entity is the formation of an host/guest complex between a cyclodextrin and an organic molecule in which the organic molecule is located inside the cavity of the cyclodextrin.[2]
Techniques as rotating-frame Overhauser enhancement spectroscopy (ROESY), which provides information on the complex structure, and Isothermal Titration Calorimetry (ITC), which allows the determination of basic thermodynamic parameters (ΔH, ΔS, ΔG and Keq) and the stoichiometry of the complex in a single experiment, are nowadays routinely used in chemical laboratories

Summary

Introduction

Supramolecular chemistry is mainly focused in designing new molecules which, after processes as recognition and assembling, form new identities denoted complexes, supramolecular assemblies, etc.[1]. The analysis of ITC experiments is straightforward when both guest and host are monotopic entities The knowledge of the microscopic equilibrium constants involved in the different equilibria will allow the determination of the existence of cooperativity (positive, negative or zero) between the different sites.

Objectives

Results

Conclusion