COMPLEX TREATMENT OF NON-OBSTRUCTIVE FORMS OF MALE INFERTILITY WITH PLATELET-RICH PLASMA, LOWINTENSITY PULSED ULTRASOUND AND HUMAN PLACENTA HYDROLYSATE

Abstract

Relevance. Male infertility is basic problem for several medical specialties from genetics and endocrinology to urology and andrology. It’s impact on personal quality of life, social functioning and existential aspects of well being and in larger scale on social health is dramatic.Aim – to develop and test complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate.Methods. The study was based on prospective parallel group design. The study contingent consisted of 46 patients of the “Men’s Health Clinic” Kiev, Ukraine, undergoing outpatient treatment for non-obstructive fertility disorders.Following methods were used: clinical (a standard set of clinical examinations to establish a preliminary diagnosis), laboratory (bacterial seeding of ejaculate for the presence of pathogenic microflora, extended spermogram); serological (evaluations of serum testosterone and luteinizing hormone levels instrumental (sonographic examination of the prostate gland in order exclude prostatic inflammation); statistical.Results. After the initial complex of examinations study contingent underwent developed treatment protocol: 6 sessions (1 session per week) of local injections of 1ml HPH «Laennec»; 6 sessions of local injections of 1ml PRP (1 session per week); 6 sessions of LIPUS (1 session per week, following HPH and PRP injections); metabolic therapy: «SaluFertil Forte» and «SALUTRIB» 6 weeks daily.Conclusion. Complex treatment model of non-obstructive forms of male infertility with combination of platelet-rich plasma, low-intensity pulsed ultrasound and human placenta hydrolysate and metabolic therapy with «SaluFertil Forte» and «SALUTRIB», showed significant efficacy in 6-week therapeutic period. Therapeutic effect was found in sperm count in 1 ml (<0,01), sperm aggregation (<0,01) and sperm mobility (group A + B) (<0,01).