Abstract
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Highlights
The cerebellum plays a significant role in many brain functions, providing information to multiple brainstem nuclei and, via the thalamus, much of the cerebral cortex
We investigate the relationship between complex spikes (CSs) and deep cerebellar nuclei (DCN) activity in order to provide a quantitative analysis of the relationship between CS synchrony and various aspects of CS-associated modulation of DCN activity
We analyze the effect of synchronous CS activity for Purkinje cell (PC) that converge onto the same DCN neuron
Summary
The cerebellum plays a significant role in many brain functions, providing information to multiple brainstem nuclei and, via the thalamus, much of the cerebral cortex. This widespread influence makes it vital to understand the factors that shape cerebellar output, which arises primarily from the deep cerebellar nuclei (DCN). The GABAergic nature of PCs suggests that an inverse relationship between PC and DCN activity should exist, and manipulations that cause global changes in PC simple spike (SS) firing rates produce the predicted inverse changes in DCN activity (MacKay and Murphy, 1973; MacKay and Murphy, 1974; Colin et al, 1980; Montarolo et al, 1982; Bardin et al, 1983; Benedetti et al, 1983). Attempts to correlate spontaneous SS activity from individual PCs with the activity of individual DCN neurons failed to reveal any consistent correlation, despite the employment of
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