Abstract
In this paper, we performed and designed a new rectangular cavity to identify and analyze the complex permittivity of two cancer cells (Breast-MDA231, Uveal melanoma) that have a high dielectric constant and dielectric loss. The rectangular cavity device is based on the improved cavity perturbation technology. The sample of the improved cavity perturbation device is placed at the position of a/n close to the wall of the cavity, where a is the wide side of the cavity and n is the positive even number. For high-loss biological materials, the improved cavity perturbation method has higher accuracy than the traditional cavity perturbation method. The results present that the relative dielectric constants of a single cell at Ka-band (26.5–40 GHz) are in the range 8–15, and the relative dielectric loss is 24–31. The information of the cancer cells at Ka-band waves can be helpful for further cancer detection and clinical treatment.
Highlights
The permittivity of material depicts the ability to permit the storage of electric energy by clarifying the relationship between the electric flux density and the electric field
Where we consider materials with high loss and large dielectric parameters, the real part of the complex permittivity calculated by the traditional perturbation Equations (1) and (2) was larger than the actual value, which has a maximum of 50% positive deviation
Theoretical and simulation results show that the proposed cavity perturbation method is especially suitable for high loss and high dielectric parameter materials, such as the measurement of complex dielectric parameters of biological materials
Summary
The permittivity of material depicts the ability to permit the storage of electric energy by clarifying the relationship between the electric flux density and the electric field It is a function of frequency and the basic physical properties of the material. We designed a new rectangular cavity device to identify and analyze the complex permittivity of two cancer cells (Breast-MDA231, Uveal melanoma), which have a high dielectric constant and dielectric loss at the Ka-band. Researchers have proposed a variety of equivalent measurement methods to indirectly measure the complex dielectric parameters of single cells by characterizing the complex dielectric properties of cell culture fluids. With the utilization of the proposed rectangular cavity perturbation method, we can obtain complex dielectric parameters for cell cultures with specific small volumes and numbers. When the complex dielectric parameters of a small amount of cell-containing culture medium are measured, Hanai’s mixed formula can be used to obtain the complex dielectric parameters of a single cell [22]
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