Abstract
Complex micelles with a hydrophobic poly(ϵ-caprolactone) (PCL) core and a mixed P(Asp-co-AspPBA)/PEG shell were prepared through co-assembly of two block copolymers PCL-b- P(Asp-co-AspPBA) and PEG-b-PCL in basic aqueous solutions. The P(Asp-co-AspPBA) chains (Asp = aspartic acid; AspPBA = aspartamidophenylboronic acid) collapsed and formed a shell layer around the PCL core at neutral pH while the soluble PEG chains stabilised the micelles. The collapsed P(Asp-co-AspPBA) polymer becomes soluble under higher glucose concentration and collapses onto the PCL core reversibly at lower glucose concentration. Self-regulated release of glibenclamide from the complex micelles was achieved based on the reversible change of P(Asp-co-AspPBA) chain mobility in response to the change of glucose concentration. As a result, polymeric micelles with glucose-responsive on-off switches were successfully developed.
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