Abstract
Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty-one CLL patients were analysed following transplant; 18-month overall survival (OS), event-free survival (EFS) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with CK (n=19) versus 83%, 68% and 29% in patients without (n=32) (P≤0·0001, P≤0·0001, and P=0·02). In patients with high-risk interphase cytogenetics, CK remained predictive of worse OS (P=0·02) and EFS (P=0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.
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