Abstract
AbstractA number of 12‐oxosteroids with both 5α‐ and 5β‐configuration and with variable side chain are reduced with LiAlH4, NaAlH4 and Li[Al(Ot‐Bu)3H] in THF and diethylether. The ratio of the epimeric 12‐alcohols obtained, exhibits a remarkable dependence on the type of A/B ring fusion and on the C‐17 substitution. An evaluation of these effects is made in the light of generally accepted rationalizations on the mechanism of ketone reductions by hydride reagents.
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