Abstract

Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus. We propose a subdivision of the species Dobrava-Belgrade virus into four related genotypes – Dobrava, Kurkino, Saaremaa, and Sochi – that show characteristic differences in their phylogeny, specific host reservoirs, geographical distribution, and pathogenicity for humans.

Highlights

  • BRIEF REVIEWComplex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

  • Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus

  • DOBV nucleic acid was detected by RT-PCR and sequencing in Greek and Albanian hemorrhagic fever with renal syndrome (HFRS) patients [1]

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Summary

BRIEF REVIEW

Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. This article is published with open access at Springerlink.com

History of DOBV discovery and characterization
DOBV hosts and evolution
Case fatality rate Available cell culture isolates
Proposal of a new classification
Virus protein
DOBV epidemiology and virulence in humans
Findings
Conclusions
Full Text
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