Complex Behaviour of Bile Salts at Various Temperatures Under the Influence of Antidepressant Drug (Imipramine) in Aqueous Solution

Shweta Singh

doi:10.11648/j.si.20160405.13

Abstract

The present method was based on the effect of bile salt (Sodium cholate and Sodium deoxy cholate) on the dissolution of Antidepressant drug like Imipramine. Sodium cholate and Sodium deoxycholate is a type of anionic surfactants form mixed micelle with Imipramine and influence its rate of dissolution. The micellization behavior of binary anionic bile salt surfactant mixtures was investigated by conductivity method and various thermodynamical parameters are calculated. The results of the study have been analyzed by using Clint’s, Rubingh’s, and Motomura’s theories for mixed binary systems.

Highlights

Surfactants word is made up of three different word “surface active agent”
Aggregation of drug and bile salts as well as their tendency to form mixed micelles having CMC's different than ideal conditions, and the nonideality is more for the binary mixtures
The binary mixture of both surfactants and drug mixture was analysed by conductometer methods

Summary

Introduction

Surfactants word is made up of three different word “surface active agent”. It has two different part -water-loving or hydrophilic and water-hating or hydrophobic. Due to presence of its unique structure it is known as amphiphilic or amphipathic molecules and due to its nature hydrophilic group of Surfactants forms hydrogen bonds with water molecules, while due to hydrophobic nature hydrocarbon chains aggregate and moving away from the water molecules Due to these properties surfactants is soluble in water. It is important to notice that lyophobic colloids, such as polymers, require certain energy to be applied for their formation, are quite unstable from the thermodynamic point of view, and frequently form large aggregates Association colloids such as micelles, on the other hand, can form spontaneously under certain conditions (self- assembling systems), and are Shweta Singh et al.: Complex Behaviour of Bile Salts at Various Temperatures Under the Influence of Antidepressant. Prepared mixtures consisted of 0.1-1 mole fractions of Sodium cholate and Sodium deoxycholate and 0.1 mole fraction of Imipramine

Materials

Effect of Drugs on the Micellization Processs of BileSalts

Development of Model

Conclusion